Use Cases and Deployment Scope
We use Mimecast Advanced Email Security as our front-end security for our 365 tenant. While 365 does offer security functionality it is rudimentary at best leaving you to configure and set up majority of the policies in order to be of any use. We didn't find this sustainable with email being a primary target for malicious actors. Mimecast Advanced Email Security offers a robust system that monitors every email both inbound and outbound for any malicious nature. They replace url links so when users click them it is first opened and scanned by Mimecast Advanced Email Security in their environment prior to the user gaining access. This has already saved us more than once.
Other Software Used
Omnissa Horizon, Untangle NG Firewall, OpenVPN Access Server, Freshservice, NinjaOne, BeyondTrust Remote Support, SmartDraw, Wing FTP Server, Dell PowerStore, Dell PowerEdge