RedHat Jboss Fuse can be used perfectly to solve application integration or microservices implementation at the departmental or enterprise level. The wide quantity of connectors it provides allows any application to be integrated. Specific technical and programming knowledge is required to build the interfaces, therefore it is not so appropriate for those companies that do not have these employee profiles.
Hands down, Mule is more cost-effective than Informatica, either on-prem or cloud, and the value only goes up form there. Reusability and ease of creation makes in-house training simple and the end result is we leverage Mule for much more than what we initially considered it for. Having used Oracle and TIBCO before as well, I find they are the tools of yesterday, not able to keep up in terms of functionality or price. Jitterbit would be a more relevant comparison, but Mule won out in the bake-off we did between them.
RedHat JBoss Fuse has a strong user community, it's fully opensource and it's easy to license with world-class support. It also has strong integration with AMQP messaging system to bring much more control and visibility over integration patterns, messaging flows, and the overall system topology.