Hands down, Mule is more cost-effective than Informatica, either on-prem or cloud, and the value only goes up form there. Reusability and ease of creation makes in-house training simple and the end result is we leverage Mule for much more than what we initially considered it for. Having used Oracle and TIBCO before as well, I find they are the tools of yesterday, not able to keep up in terms of functionality or price. Jitterbit would be a more relevant comparison, but Mule won out in the bake-off we did between them.