Prophet 21 has been utilized by various departments within organizations to streamline and improve their operations. For example, Counter Staff have experienced faster and more efficient sales transactions when processing quotes and orders. The Purchasing Department has found value in using Prophet 21 to simplify the procurement process by submitting purchase orders from part vendors. Additionally, the AR and AP Departments have relied on Prophet 21 to ensure accurate and timely financial transactions, specifically by invoicing customers and paying vendors. With its integrated solution, Prophet 21 has enhanced inventory accuracy, reduced picking errors, and maintained optimal inventory levels. It has also supported various operations such as order processing, inventory management, customer information, and accounting as an ERP software. The open database structure of Prophet 21 has allowed users to access information in any format, aiding in informed decision-making. Customers have even used Prophet 21 to run their entire business, including accounting, sales, and inventory management.

Furthermore, Prophet 21 has facilitated seamless collaboration across multiple locations through its deployment throughout the organization. Pricing and purchasing management have greatly benefited from this software. With Prophet 21's help, wholesale distribution businesses have experienced growth. It has proven effective in managing wholesale stock by enabling users to efficiently process incoming and outgoing stock and inventory. Moreover, the software's compatibility with different business models has made it a valuable tool for organizations across industries.

While some users have mentioned that the software can be complicated at times, most find that it effectively manages inventory and fulfills its purpose well. The technical support provided by Epicor has been praised for being a good fit for supporting staff in resolving any issues that may arise. Prophet 21 has contributed to improved efficiency in various areas such as service order entry, machine and tooling order entry, CRM management, order entry inquiries, transaction processing, KPI tracking, decision-making support, inventory tracking across multiple warehouses, dynamic reporting dashboards, employee onboarding acceleration, rewards program creation and tracking, and consignment management. It has also proved valuable for website integration, reporting through Crystal and other third-party programs, customizing screens using Dynachange, and providing access to real-time data across all company locations. Overall, users have found Prophet 21 to be a valuable tool for their businesses, with continuous improvements based on customer feedback.