DevExpress can help you create the big web app of your dreams. DevExpress works great with data-centered enterprise-level applications that require the use of enterprise-grade data grids, pivottables, and integrate them with all the widgets like buttons, popups, forms, etc. I would not recommend DevExpress for small apps that require only basic widgets like radio/select boxes, buttons, text boxes, etc. You can get those widgets for free or even make your own.
If you need a fast, robust and reliable server side framework that allows you to write JS on the backend and therefore have your project in one language - Node.js is a stand out choice. It can easily handle heavy traffic on very little resources (CPU and memory usage is very efficient). I can't recommend it enough, it is such a pleasure to work with - I feel it gave me back my career. I was so bored with the banality of .NET, I had also come to dislike it's overly convoluted and complicated class structure. Node.js was the fresh start I needed, it can be as simple or as complicated as you like - but even at it's most complicated it can still beat the pants off .NET core any day.
Node.js is easy and good to use, their support team is also good they always tend to help you, and solve your problem, even we know that Node is free to use and opensource but then also we get support from them but for getting much better results we need to purchase standard or enterprises support provided by them.